Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057715 | 0.92 | MTNR1A (0.47) | MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL3053168 | 0.91 | MTNR1A (0.47) | MTNR1AMTNR1BHTR2AHTR2CALDH1A1 | |
| SCHEMBL3058587 | 0.88 | MTNR1A (0.48) | MTNR1AMTNR1BHTR2AHTR2CALDH1A1 | |
| SCHEMBL3053598 | 0.83 | MTNR1A (0.53) | MTNR1AMTNR1BHTR2AHTR2CALDH1A1 | |
| SCHEMBL3060093 | 0.83 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1KDM4EMEN1 | |
| SCHEMBL3058774 | 0.82 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1HTTKDM4E | |
| SCHEMBL3053869 | 0.81 | MTNR1A (0.52) | MTNR1AMTNR1BHTR2AHTR2CALDH1A1 | |
| SCHEMBL3056854 | 0.80 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1KDM4EMEN1 | |
| SCHEMBL3054181 | 0.80 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1KDM4EMEN1 | |
| SCHEMBL3052990 | 0.80 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026446-A9 | HDAC INHIBITORS | ARQULE, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009026446-A2 | HDAC INHIBITORS | ARQULE, INC. (US) | 2009-02-26 | — | — | WO | disclosed |