Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 16/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.43 |
| ▸ | ATR | Q13535 | 14/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 14/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 8/20 | 0.39 |
| ▸ | MTOR | P42345 | 8/20 | 0.38 |
| ▸ | SERPINA2 | P20848 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807838 | 0.88 | PIK3CA (0.44) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL15131801 | 0.88 | PIK3CB (0.41) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL17243667 | 0.87 | PRKDC (0.48) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL15131806 | 0.86 | PIK3CB (0.47) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL15131807 | 0.84 | PRKDC (0.52) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL807817 | 0.83 | PI4KA (0.52) | PIK3CBPIK3CA | |
| SCHEMBL15131808 | 0.82 | PRKDC (0.44) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL15131800 | 0.82 | PIK3CB (0.42) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL15131803 | 0.78 | MAP4K4 (0.44) | PRKDCPIK3CBATRATRIPMAP4K4 | |
| SCHEMBL17243665 | 0.78 | PIK3CA (0.42) | PRKDCPIK3CBATRATRIPMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |