Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 19/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 19/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.52 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131799 | 0.90 | PI4KA (0.48) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL807839 | 0.83 | PRKDC (0.43) | PIK3CAPIK3CB | |
| SCHEMBL807826 | 0.83 | PI4KA (0.45) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL807838 | 0.80 | PIK3CA (0.44) | PI4KBPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL10070633 | 0.79 | PI4KA (0.46) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL807985 | 0.78 | PIK3CA (0.45) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL807982 | 0.78 | MET (0.45) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL15131809 | 0.76 | PIK3CA (0.43) | PI4KAPI4KBPIK3CAPIK3CDPIK3CB | |
| SCHEMBL807973 | 0.74 | ATM (0.41) | PI4KBPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL807975 | 0.73 | PRKDC (0.44) | PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |