Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | WNT1 | P04628 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797194 | 0.93 | ABL1 (0.51) | ABL1PIM1PIM2GSK3BPDGFRB | |
| SCHEMBL27904307 | 0.84 | ABL1 (0.41) | ABL1PDGFRBPDGFRAHCAR2HDAC4 | |
| SCHEMBL797117 | 0.80 | KMT2A (0.47) | ABL1 | |
| SCHEMBL2621749 | 0.78 | PDGFRB (0.45) | DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL19516307 | 0.71 | ABL1 (0.76) | ABL1DYRK1AGSK3BWNT1 | |
| SCHEMBL30005555 | 0.71 | ABL1 (0.76) | ABL1DYRK1AGSK3BWNT1 | |
| SCHEMBL808070 | 0.71 | PDGFRB (0.39) | PDGFRBPDGFRACYP1A2CYP2C19 | |
| SCHEMBL15133612 | 0.70 | CA1 (0.39) | ABL1PIM1GAAHDAC4 | |
| SCHEMBL20951979 | 0.68 | DYRK1A (0.62) | ABL1PIM1PIM2DYRK1AGSK3B | |
| SCHEMBL28750182 | 0.68 | ABL1 (0.44) | ABL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |