Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621736 | 0.89 | PDGFRB (0.41) | PDGFRBPDGFRAHTTCYP1A2CYP2C19 | |
| SCHEMBL780200 | 0.82 | PABPC1 (0.42) | PDGFRBPDGFRAHTTCYP1A2CYP2C19 | |
| SCHEMBL796733 | 0.81 | PABPC1 (0.41) | PDGFRBPDGFRAHTTCYP1A2CYP2C19 | |
| SCHEMBL30359519 | 0.81 | PABPC1 (0.41) | PDGFRBPDGFRAHTTCYP1A2CYP2C19 | |
| SCHEMBL2621754 | 0.80 | HTT (0.49) | PDGFRBPDGFRAHTTCYP1A2CYP2C19 | |
| SCHEMBL23246999 | 0.79 | EGFR (0.43) | PDGFRBPDGFRAHTTKDM4EHSP90AA1 | |
| SCHEMBL26654324 | 0.77 | BACE1 (0.50) | HTTCYP1A2CYP2C19PABPC1KDM4E | |
| SCHEMBL797194 | 0.74 | ABL1 (0.51) | PDGFRBPDGFRACYP1A2CYP2C19 | |
| SCHEMBL1639504 | 0.74 | HTT (0.41) | HTTCYP1A2CYP2C19PABPC1KDM4E | |
| SCHEMBL2621734 | 0.74 | EGFR (0.47) | CYP2C19KDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |