Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19612320 | 0.83 | ESR1 (0.50) | ESR1ESR2MAOBABL1ABCB1 | |
| SCHEMBL806517 | 0.81 | ACHE (0.54) | MAOBKDM2BTDP1POLBMEN1 | |
| SCHEMBL11075536 | 0.80 | CYP11B1 (0.51) | ESR1ESR2MAOBABL1ABCB1 | |
| SCHEMBL30503987 | 0.79 | CA12 (0.52) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL4194130 | 0.79 | CA12 (0.52) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL5752998 | 0.78 | POLB (0.55) | KDM2BPOLBMEN1KMT2A | |
| SCHEMBL8709973 | 0.77 | CYP1A2 (0.46) | ESR1ESR2MAOBATMTDP1 | |
| SCHEMBL1477716 | 0.77 | ESR1 (0.56) | ESR1ESR2MAOBABL1ABCB1 | |
| Flavanthrinin SCHEMBL30544846 | 0.76 | ESR1 (0.51) | ESR1ESR2MAOBABL1ABCB1 | |
| Flavanthrinin SCHEMBL29054933 | 0.76 | ESR1 (0.51) | ESR1ESR2MAOBABL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710367-B1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5637262-A | REVERSIBLE PHOTOCHROMIC DYES FOR OPHTHALMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0710367-A4 | — | — | 1996-05-15 | — | — | EP | disclosed |
| EP-0710367-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5466398-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1995000867-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | disclosed |