Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343253 | 0.82 | POLB (0.58) | POLBKDM4EATMCXCR2MEN1 | |
| SCHEMBL13970426 | 0.81 | CXCR2 (0.57) | CXCR2CCR6CXCR1 | |
| SCHEMBL16176968 | 0.80 | G6PD (0.55) | POLBKDM4EATMMEN1KMT2A | |
| SCHEMBL8061202 | 0.80 | KDM4E (0.47) | POLBKDM4EATMMEN1KMT2A | |
| SCHEMBL11552313 | 0.80 | KDM4E (0.47) | POLBKDM4EATM | |
| SCHEMBL22797015 | 0.79 | POLB (0.43) | POLBKDM4EATMCXCR2MEN1 | |
| SCHEMBL8082335 | 0.78 | MEN1 (0.47) | POLBKDM4ECXCR2MEN1KMT2A | |
| SCHEMBL940016 | 0.77 | KDM4E (0.68) | POLBKDM4EATMMEN1KMT2A | |
| SCHEMBL7780207 | 0.77 | G6PD (0.55) | POLBKDM4ECXCR2MEN1KMT2A | |
| SCHEMBL8828492 | 0.77 | SMN1; SMN2 (0.46) | KDM4ECXCR2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |