Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326853 | 0.90 | APP (0.56) | MAOBAPPOPRM1CHRM2HTR1A | |
| SCHEMBL2538898 | 0.88 | MEN1 (0.53) | MAOBAPPKDM4ECNR2TSHR | |
| SCHEMBL15466880 | 0.84 | MAOB (0.50) | MAOBAPPKDM4ECNR2TSHR | |
| SCHEMBL11464709 | 0.83 | MEN1 (0.50) | KCNH2MEN1 | |
| SCHEMBL17346229 | 0.82 | MAOB (0.43) | MAOBAPPKDM4ECNR2TSHR | |
| SCHEMBL8113477 | 0.82 | MAOB (0.47) | MAOBAPPKDM4EOPRM1BCHE | |
| SCHEMBL15303616 | 0.82 | APP (0.48) | MAOBAPPCNR2OPRM1CHRM2 | |
| SCHEMBL7200272 | 0.82 | APP (0.48) | APPOPRM1CHRM2HTR1AADRA2A | |
| SCHEMBL18657229 | 0.81 | APP (0.50) | MAOBAPPKDM4EOPRM1BCHE | |
| SCHEMBL22873879 | 0.81 | APP (0.49) | MAOBAPPBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |
| EP-0429149-A1 | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. (US) | 1991-05-29 | — | — | EP | disclosed |