Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.54 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28964080 | 0.77 | TSHR (0.67) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL18069230 | 0.77 | TSHR (0.67) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL10641630 | 0.77 | TSHR (0.67) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL28459672 | 0.76 | ESR1 (0.61) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL28591660 | 0.76 | ESR1 (0.61) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2538613 | 0.74 | TSHR (0.63) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL27687278 | 0.74 | ALDH1A1 (0.77) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL18109769 | 0.72 | TSHR (0.73) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL18106214 | 0.72 | TSHR (0.73) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19348915 | 0.72 | TSHR (0.73) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033986-A1 | FORMULATIONS COMPRISING DISSOLVED PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-09-13 | — | — | EP | disclosed |
| WO-1999026625-A1 | FORMULATIONS COMPRISING DISSOLVED PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 1999-06-03 | — | — | WO | disclosed |