Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.38 |
| ▸ | PRKDC | P78527 | 7/20 | 0.38 |
| ▸ | ATR | Q13535 | 6/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.38 |
| ▸ | ATM | Q13315 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | SERPINA2 | P20848 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807983 | 0.93 | PIK3CA (0.43) | GRIN1GRIN2BPIK3CAMAP4K4PIK3CB | |
| SCHEMBL15131803 | 0.87 | MAP4K4 (0.44) | GRIN1GRIN2BMAP4K4PIK3CBPRKDC | |
| SCHEMBL10070628 | 0.85 | PIK3CA (0.46) | GRIN1GRIN2BPIK3CAPIK3CBPRKDC | |
| SCHEMBL796867 | 0.84 | PIK3CA (0.43) | PIK3CAPIK3CBPRKDCATRATRIP | |
| SCHEMBL807989 | 0.83 | PIK3CA (0.47) | GRIN1GRIN2BPIK3CAPIK3CBPRKDC | |
| SCHEMBL17243665 | 0.82 | PIK3CA (0.42) | PIK3CAMAP4K4PIK3CBPRKDCATR | |
| SCHEMBL807819 | 0.80 | PIK3CA (0.43) | GRIN1GRIN2BPIK3CAPIK3CBPRKDC | |
| SCHEMBL10070630 | 0.80 | PIK3CA (0.46) | GRIN2BPIK3CAPIK3CBPRKDCATR | |
| SCHEMBL17243957 | 0.80 | PIK3CA (0.47) | PIK3CAMAP4K4PIK3CBPRKDCATR | |
| SCHEMBL807838 | 0.80 | PIK3CA (0.44) | PIK3CAMAP4K4PIK3CBPRKDCATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181264-B2 | Fused heteroaryls and their uses | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-07-25 | — | — | US | disclosed |
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | FARS2, TIAL1, DHFR | GRIN1 2260/4885GRIN2B 1249/4885PIK3CA 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.