Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1439601 | 0.85 | TSHR (0.39) | ALDH1A1SMN1; SMN2CYP3A4FFAR3LMNA | |
| SCHEMBL1440918 | 0.83 | TSHR (0.40) | ALDH1A1SMN1; SMN2CYP3A4FFAR3LMNA | |
| SCHEMBL11167364 | 0.81 | APOBEC3A (0.35) | ALDH1A1SMN1; SMN2FFAR3TSHR | |
| SCHEMBL11155103 | 0.77 | KDM4E (0.39) | ALDH1A1SMN1; SMN2FFAR3LMNAMEN1 | |
| SCHEMBL14961961 | 0.77 | TSHR (0.44) | ALDH1A1SMN1; SMN2CYP3A4FFAR3LMNA | |
| SCHEMBL23604357 | 0.76 | PKM (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12306234 | 0.76 | TSHR (0.36) | ALDH1A1SMN1; SMN2CYP3A4FFAR3ABCB11 | |
| SCHEMBL1439885 | 0.76 | FFAR3 (0.34) | ALDH1A1SMN1; SMN2FFAR3NPSR1CETP | |
| SCHEMBL29642954 | 0.75 | FFAR3 (0.37) | ALDH1A1SMN1; SMN2CYP3A4FFAR3ABCB11 | |
| SCHEMBL2287208 | 0.75 | BRD4 (0.41) | ALDH1A1SMN1; SMN2FFAR3LMNAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848426-B1 | TRICYCLIC CYTOPROTECTIVE COMPOUNDS | HUNTER FLEMING LTD (GB) | 2012-08-01 | — | — | EP | disclosed |
| EP-1040096-A1 | NEUROPROTECTIVE AGENTS | THE UNIVERSITY OF SOUTHAMPTON (GB) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031049-A1 | NEUROPROTECTIVE AGENTS | UNIVERSITY OF SOUTHAMPTON (GB) | 1999-06-24 | — | — | WO | disclosed |