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Diphenylmethanol

Diphenylmethanol

SCHEMBL8080244

Cc1ccc(Oc2ccccc2C(=O)O)c(NS(=O)(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1.OC(c1ccccc1)c1ccccc1

nearest known ligand 0.59

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CCR2 P41597 14/20 0.59
▸ CCR1 P32246 4/20 0.59
▸ CYP1A2 P05177 1/20 0.48
▸ CYP3A4 P08684 1/20 0.48
▸ CYP2D6 P10635 1/20 0.48
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ CCR4 P51679 1/20 0.48
▸ CCR5 P51681 1/20 0.48
▸ KCNH2 Q12809 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ ACLY P53396 3/20 0.46
▸ METAP2 P50579 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5664918 0.94 CCR2 (0.66) CCR2CCR1CYP1A2CYP3A4CYP2D6
Diphenylmethanol SCHEMBL8075173 0.92 CCR2 (0.70) CCR2CCR1CYP1A2CYP3A4CYP2D6
Diphenylmethanol SCHEMBL8075194 0.91 CCR2 (0.60) CCR2CCR1CYP1A2CYP3A4CYP2D6
SCHEMBL8080241 0.87 CCR2 (0.51) CCR2CCR1CYP1A2CYP3A4CYP2D6
Diphenylmethanol SCHEMBL8075196 0.86 CCR2 (0.75) CCR2CCR1CYP1A2CYP3A4CYP2D6
Diphenylmethanol SCHEMBL8067191 0.85 CCR2 (0.77) CCR2CCR1CYP1A2CYP3A4CYP2D6
SCHEMBL30410481 0.85 CCR2 (0.79) CCR2CCR1CYP1A2CYP3A4CYP2D6
SCHEMBL5665013 0.85 CCR2 (0.79) CCR2CCR1CYP1A2CYP3A4CYP2D6
Diphenylmethanol SCHEMBL8067139 0.84 CCR2 (0.75) CCR2CCR1CYP1A2CYP3A4CYP2D6
SCHEMBL5666146 0.84 CCR2 (0.67) CCR2CCR1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0799198-B1 ANTI-INFLAMMATORY COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2000-08-30 — — EP disclosed
EP-0799198-A4 — — 1997-10-15 — — EP disclosed
EP-0799198-A1 ANTI-INFLAMMATORY COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1997-10-08 — — EP disclosed
US-5545669-A Anti-inflammatory compounds SMITHKLINE BEECHAM CORPORATION 1996-08-13 — — US disclosed
WO-1995033461-A1 ANTI-INFLAMMATORY COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1995-12-14 — — WO disclosed