Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 7/20 | 0.66 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.62 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.62 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734803 | 0.87 | ITGAV (0.67) | ITGAVSLC1A3SLC1A2SLC1A1HTT | |
| SCHEMBL1734801 | 0.87 | ITGAV (0.67) | ITGAVSLC1A3SLC1A2SLC1A1HTT | |
| SCHEMBL8093821 | 0.82 | GBA1 (0.56) | ITGAVALDH1A1MMP2MMP9 | |
| SCHEMBL27575200 | 0.80 | SLC1A3 (0.64) | ITGAVSLC1A3SLC1A2SLC1A1KDM4E | |
| SCHEMBL5840519 | 0.80 | SLC1A3 (0.64) | ITGAVSLC1A3SLC1A2SLC1A1KDM4E | |
| SCHEMBL383079 | 0.80 | MMP2 (0.61) | SLC1A3SLC1A2SLC1A1ALDH1A1MMP2 | |
| SCHEMBL6500230 | 0.80 | MMP2 (0.61) | SLC1A3SLC1A2SLC1A1ALDH1A1MMP2 | |
| Hydrochloric Acid SCHEMBL6499290 | 0.79 | SLC1A3 (0.62) | ITGAVSLC1A3SLC1A2SLC1A1KDM4E | |
| Hydrochloric Acid SCHEMBL382133 | 0.78 | MMP2 (0.59) | SLC1A3SLC1A2SLC1A1ALDH1A1MMP2 | |
| Hydrochloric Acid SCHEMBL7336920 | 0.78 | MMP2 (0.59) | SLC1A3SLC1A2SLC1A1ALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051625-A1 | ASSESSING RISK FOR INTEGRIN ANTAGONIST/AGONIST MEDIATED DISEASES | Du Pont Pharmaceuticals Company (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038014-A1 | ASSESSING RISK FOR INTEGRIN ANTAGONIST/AGONIST MEDIATED DISEASES | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-07-29 | — | — | WO | disclosed |