Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057617 | 0.90 | MTNR1A (0.59) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3048558 | 0.81 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3058490 | 0.81 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3064510 | 0.80 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3058846 | 0.80 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3058925 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL3053598 | 0.79 | MTNR1A (0.53) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL3048611 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL3064878 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL3053869 | 0.78 | MTNR1A (0.52) | MTNR1AMTNR1BKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026446-A9 | HDAC INHIBITORS | ARQULE, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009026446-A2 | HDAC INHIBITORS | ARQULE, INC. (US) | 2009-02-26 | — | — | WO | disclosed |