Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | PLD2 | O14939 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | C5 | P01031 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072899 | 0.88 | CNR1 (0.61) | ESR1ESR2TDP1CNR1CNR2 | |
| SCHEMBL14559000 | 0.84 | ESR1 (0.70) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8082455 | 0.83 | ESR1 (0.61) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL7107598 | 0.82 | ESR1 (0.75) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL11550840 | 0.81 | CNR1 (0.71) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL11552368 | 0.79 | ESR1 (0.75) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8080684 | 0.79 | ESR1 (0.64) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL11552941 | 0.79 | CNR1 (0.71) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL11546554 | 0.79 | CNR1 (0.67) | ESR1ESR2TDP1CNR1ALDH1A1 | |
| SCHEMBL7075664 | 0.79 | ESR1 (0.74) | ESR1ESR2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090843-A | POSTMENOPAUSE DISEASES; ESTROGEN SENSITIVITY; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | claimed |
| EP-0902025-A2 | Benzothiophenes for treatment of estrogen related conditions | ELI LILLY AND COMPANY (US) | 1999-03-17 | — | — | EP | claimed |
| US-6090843-A | POSTMENOPAUSE DISEASES; ESTROGEN SENSITIVITY; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | disclosed |