Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.61 |
| ▸ | CNR2 | P34972 | 3/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.56 |
| ▸ | TUBB | P07437 | 2/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 9/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080681 | 0.88 | ESR1 (0.58) | CNR1CNR2ESR1ESR2TDP1 | |
| SCHEMBL7104458 | 0.86 | CNR2 (0.76) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075367 | 0.86 | CNR1 (0.69) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11546641 | 0.84 | TUBB4A (0.69) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11547494 | 0.84 | CNR2 (0.76) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11547042 | 0.83 | CNR1 (0.70) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL8082353 | 0.83 | TUBB4A (0.59) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL5026252 | 0.83 | CNR1 (0.78) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11546554 | 0.81 | CNR1 (0.67) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL8072902 | 0.80 | ESR1 (0.64) | CNR1CNR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090843-A | POSTMENOPAUSE DISEASES; ESTROGEN SENSITIVITY; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | claimed |
| EP-0902025-A2 | Benzothiophenes for treatment of estrogen related conditions | ELI LILLY AND COMPANY (US) | 1999-03-17 | — | — | EP | claimed |
| US-6090843-A | POSTMENOPAUSE DISEASES; ESTROGEN SENSITIVITY; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | disclosed |