Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080512 | 0.90 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30760538 | 0.83 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL7348216 | 0.83 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL11679118 | 0.78 | PDE4A (0.38) | ALDH1A1SMN1; SMN2GSRTXNRD1LMNA | |
| SCHEMBL15218851 | 0.75 | POLB (0.36) | MAPT | |
| SCHEMBL628550 | 0.74 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL29724281 | 0.74 | POLB (0.35) | ALDH1A1SMN1; SMN2TXNRD1MAPTMEN1 | |
| SCHEMBL14140107 | 0.73 | MAPT (0.31) | MAPT | |
| SCHEMBL15218862 | 0.72 | — | — | |
| SCHEMBL11678721 | 0.70 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1SMN1; SMN2GSRTXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |
| EP-0429149-A1 | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. (US) | 1991-05-29 | — | — | EP | disclosed |