SCHEMBL808148

SCHEMBL808148

C1=CC2=C(CC1)c1ccccc1C21c2ccccc2-c2ccc(Nc3ccc4c(c3)C3(c5ccccc5-c5ccccc53)c3ccccc3-4)cc21

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 2/20 0.39
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19217060 0.95 PDK2 (0.45) PDK2MAPK14
SCHEMBL23137961 0.92 ALDH1A1 (0.38) PDK2
SCHEMBL16372107 0.85 KMT2A (0.35)
SCHEMBL25821481 0.84 PDK2 (0.35) PDK2MAPK14
SCHEMBL26084164 0.84 PDK2 (0.34) PDK2
SCHEMBL12835463 0.82 PDK2 (0.37) PDK2
SCHEMBL808140 0.82 PDK2 (0.31) PDK2
SCHEMBL19257509 0.82 PDK2 (0.40) PDK2
SCHEMBL20734798 0.82 SMN1; SMN2 (0.41) PDK2
SCHEMBL13662375 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012034627-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2012-03-22 WO disclosed