Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.45 |
| ▸ | RARG | P13631 | 5/20 | 0.45 |
| ▸ | RARA | P10276 | 4/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373360 | 0.84 | RARB (0.45) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL9188117 | 0.84 | RARB (0.48) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL4370337 | 0.81 | RARB (0.43) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL3456678 | 0.79 | RARB (0.51) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL10557225 | 0.79 | RARB (0.44) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL9190581 | 0.79 | RARB (0.53) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8293244 | 0.76 | RARA (0.49) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL18211725 | 0.76 | MAP3K14 (0.50) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL2599701 | 0.75 | RARA (0.48) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL9053722 | 0.75 | RARA (0.48) | RARBRARGRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740665-B1 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | ALLERGAN SALES INC (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-0740665-A1 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | Allergan (US) | 1996-11-06 | — | — | EP | disclosed |
| US-5519150-A | Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates | ALLERGAN (US) | 1996-05-21 | — | — | US | disclosed |
| WO-1995019973-A2 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | ALLERGAN (US) | 1995-07-27 | — | — | WO | disclosed |
| US-5420295-A | Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates | ALLERGAN, INC. (US) | 1995-05-30 | — | — | US | disclosed |