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Arginine

Arginine

SCHEMBL8082095

CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.C[C@H](N)C(=O)OC(=O)CN.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 7/20 0.37
▸ NPY1R P25929 5/20 0.37
▸ THRB P10828 1/20 0.36
▸ NPY2R P49146 4/20 0.35
▸ NPY5R Q15761 4/20 0.35
▸ KEAP1 Q14145 1/20 0.35
▸ TFPI P10646 1/20 0.35
▸ VIPR2 P41587 5/20 0.34
▸ VIPR1 P32241 3/20 0.34
▸ KISS1R Q969F8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL28007871 0.84 TFPI (0.38) NPY4RNPY1RTHRBNPY2RNPY5R
Arginine SCHEMBL17967701 0.82 NPY4R (0.36) NPY4RNPY1RTHRBNPY2RNPY5R
Arginine SCHEMBL14856223 0.81 NPY4R (0.43) NPY4RNPY1RNPY2RNPY5RKISS1R
Arginine SCHEMBL14856222 0.81 NPY4R (0.43) NPY4RNPY1RNPY2RNPY5RKISS1R
Arginine SCHEMBL28979628 0.81 NPY4R (0.42) NPY4RNPY1RTHRBNPY2RNPY5R
Arginine SCHEMBL296029 0.81 KDM1A (0.35) NPY4RNPY1RKEAP1KISS1R
Arginine SCHEMBL27692294 0.80 ANPEP (0.48) NPY4RNPY1RNPY2RNPY5RKISS1R
Arginine SCHEMBL16323075 0.80 ANPEP (0.48) NPY4RNPY1RNPY2RNPY5RKISS1R
Arginine SCHEMBL2197566 0.80 TFPI (0.36) KEAP1TFPI
Arginine SCHEMBL19668411 0.79 THRB (0.38) THRBTFPIVIPR2VIPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042486-A1 PLANT GALACTOSE DEHYDROGENASE Ascorbex Limited (GB) 2000-10-11 — — EP disclosed
WO-1999033995-A1 PLANT GALACTOSE DEHYDROGENASE ASCORBEX LIMITED (GB) 1999-07-08 — — WO disclosed