Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31137328 | 0.82 | HTR2A (0.47) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL3794977 | 0.80 | EED (0.43) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL3793855 | 0.77 | EED (0.41) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL34462948 | 0.77 | EED (0.43) | HTR2AHTR2CTAAR1EEDKCNH2 | |
| SCHEMBL28181295 | 0.77 | EED (0.43) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL2610674 | 0.76 | GABRA1 (0.46) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL2094027 | 0.74 | EED (0.41) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL20354322 | 0.73 | GABRA1 (0.48) | HTR2AHTR2CEEDKCNH2 | |
| SCHEMBL24336535 | 0.72 | EED (0.43) | HTR2AHTR2CEEDKCNH2KDM4E | |
| SCHEMBL5541627 | 0.72 | EED (0.40) | HTR2AHTR2CEEDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063810-A | ENANTIOMORPHS | SYNTHELABO (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0688320-B1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK AS (DK) | 1999-05-06 | — | — | EP | disclosed |
| US-5512562-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOSIS, DEPRESSION, SLEEP DISORDERS, PARKINSON*S DISEASE, STROKE | NOVO NORDISK A/S (DK) | 1996-04-30 | — | — | US | disclosed |
| EP-0688320-A1 | TRICYCLIC BENZODIAZEPINS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1995-12-27 | — | — | EP | disclosed |
| WO-1994020472-A1 | HETEROCYCLIC COMPOUNDS, THEIR USE AND PREPARATION | NOVO NORDISK A/S (DK) | 1994-09-15 | — | — | WO | disclosed |