Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752257 | 0.87 | LMNA (0.57) | LMNAGAAPTGS1CXCR5PPIA | |
| SCHEMBL15825667 | 0.80 | LMNA (0.49) | LMNAGAAPTGS1CXCR5PPIA | |
| SCHEMBL3753308 | 0.79 | GAA (0.48) | LMNAGAACXCR5PPIAKCNK3 | |
| SCHEMBL3308725 | 0.77 | CXCR5 (0.71) | LMNAGAACXCR5 | |
| SCHEMBL961793 | 0.74 | LMNA (0.66) | LMNAGAAPTGS1PPIAKCNK3 | |
| SCHEMBL1128084 | 0.74 | LMNA (0.70) | LMNAGAAPTGS1PPIAKCNK3 | |
| SCHEMBL9830646 | 0.73 | GAA (0.75) | LMNAGAAPTGS1PPIAKCNK3 | |
| SCHEMBL16372245 | 0.73 | LMNA (0.51) | LMNAGAAPTGS1PPIAKCNK3 | |
| SCHEMBL8653738 | 0.73 | LMNA (0.64) | LMNAGAAPTGS1PPIAKCNK3 | |
| SCHEMBL464462 | 0.72 | PSMB5 (0.76) | LMNAGAACXCR5PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212334-B1 | PROTEASOME INHIBITORS | MILLENNIUM PHARM INC (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2009051581-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |