Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15804003 | 0.88 | RECQL (0.74) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL1896629 | 0.84 | GAA (0.53) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL15804000 | 0.83 | RECQL (0.61) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL25434321 | 0.79 | RECQL (0.55) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL21685620 | 0.76 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL16794652 | 0.76 | RECQL (0.52) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL21684646 | 0.76 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL17603200 | 0.76 | RECQL (0.55) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL | |
| SCHEMBL8077068 | 0.76 | MAPT (0.62) | ALDH1A1SMN1; SMN2L3MBTL1MAPTTHRB | |
| SCHEMBL13075102 | 0.75 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HTTL3MBTL1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518975-B2 | Gamma secretase modulators | Merck Sharp + Dohme Corp. (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518975-B2 | Gamma secretase modulators | Merck Sharp + Dohme Corp. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-04-07 | — | — | US | disclosed |
| WO-2009032277-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | ALDH1A1 1705/4885SMN1; SMN2 1223/4885HTT 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.