Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070874 | 0.89 | SRD5A2 (0.57) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8070499 | 0.84 | SRD5A2 (0.68) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8433669 | 0.84 | SRD5A2 (0.71) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL6539644 | 0.82 | SRD5A2 (0.60) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8437275 | 0.75 | SRD5A2 (0.74) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8433302 | 0.72 | SRD5A2 (0.70) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8070861 | 0.72 | SRD5A2 (0.74) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8070858 | 0.72 | SRD5A2 (1.00) | MEN1KMT2APKMSRD5A2NPC1 | |
| SCHEMBL8082813 | 0.70 | SRD5A2 (0.68) | MEN1KMT2APKMSRD5A2ALDH1A1 | |
| SCHEMBL8080185 | 0.70 | SRD5A2 (0.63) | MEN1KMT2APKMSRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |