SCHEMBL8083442

SCHEMBL8083442

[c]1ccc(CCC(CCCc2ccccn2)c2ccccc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.40
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2A Q12879 1/20 0.39
GRIN2B Q13224 1/20 0.39
GRIN2C Q14957 1/20 0.39
GRIN3A Q8TCU5 1/20 0.39
CYP1A2 P05177 3/20 0.39
CYP2C19 P33261 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP19A1 P11511 1/20 0.39
ABCB1 P08183 1/20 0.37
HTR1A P08908 1/20 0.37
DRD2 P14416 1/20 0.37
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.35
HRH3 Q9Y5N1 2/20 0.35
HRH4 Q9H3N8 1/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570932 0.83 CYP19A1 (0.46) CYP19A1
SCHEMBL8191565 0.80 HRH1 (0.51) HRH1CYP1A2CYP2C19SMN1; SMN2ABCB1
SCHEMBL6571451 0.78 TSHR (0.39) SMN1; SMN2CYP19A1ABCB1HTR1ADRD2
SCHEMBL8095259 0.78 CYP2A6 (0.43) HRH1CYP19A1
SCHEMBL1712424 0.76 CYP1A2 (0.56) HRH1CYP1A2CYP2C19SMN1; SMN2ABCB1
SCHEMBL7426041 0.76 CFTR (0.41) CYP1A2CYP2C19SMN1; SMN2CYP19A1CYP3A4
SCHEMBL5332634 0.75 HTR2A (0.41) CYP19A1HTR1A
SCHEMBL11712943 0.74 CYP19A1 (0.39) CYP19A1CYP3A4CYP2D6
SCHEMBL1170712 0.72 CYP19A1 (0.40) CYP19A1CYP3A4CYP2D6
SCHEMBL8721706 0.71 HRH1 (0.49) HRH1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6124328-A TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA VERTEX PHARMACEUTICALS INCORPORATED (US) 2000-09-26 US disclosed
US-6037370-A TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES VERTEX PHARMACEUTICALS INCORPORATED (US) 2000-03-14 US disclosed