Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM3 | Q14832 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.45 |
| ▸ | GCLC | P48506 | 1/20 | 0.43 |
| ▸ | P2RY10 | O00398 | 4/20 | 0.42 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23934118 | 0.87 | FOLH1 (0.54) | GRM3FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL1374889 | 0.83 | GRM3 (0.69) | GRM3FOLH1GCLCNAALAD2 | |
| SCHEMBL23934133 | 0.82 | FOLH1 (0.51) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL21804883 | 0.82 | FOLH1 (0.51) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL23934124 | 0.82 | FOLH1 (0.51) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL23934126 | 0.82 | FOLH1 (0.51) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL9290907 | 0.78 | DGKA (0.48) | P2RY10GPR34 | |
| SCHEMBL21805747 | 0.76 | P2RY10 (0.53) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL23934115 | 0.76 | P2RY10 (0.53) | FOLH1P2RY10GPR34NAALAD2 | |
| SCHEMBL4868941 | 0.75 | FOLH1 (0.50) | GRM3FOLH1GCLCNAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044206-A1 | PRODRUGS OF NAALADASE INHIBITORS | Guildford Pharmaceuticals Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| CN-1230889-A | NAALADase compositions and methods for treating glutamate abnormalities and for producing neuronal activity in animals | GUILFORD PHARM INC (US) | 1999-10-06 | — | — | CN | disclosed |
| WO-1999033849-A1 | PRODRUGS OF NAALADASE INHIBITORS | GUILDFORD PHARMACEUTICALS INC. (US) | 1999-07-08 | — | — | WO | disclosed |