Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891808 | 0.96 | ACHE (0.43) | DHODHPARP1ACHEMEN1KMT2A | |
| SCHEMBL8891268 | 0.96 | ACHE (0.43) | DHODHPARP1ACHEMEN1KMT2A | |
| SCHEMBL8892025 | 0.95 | ACHE (0.42) | DHODHDRD2PARP1ACHEMEN1 | |
| SCHEMBL8817597 | 0.89 | ACHE (0.42) | DHODHACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL8071362 | 0.87 | DHODH (0.47) | DHODHHRH3DRD3KCNH2DRD2 | |
| SCHEMBL8079646 | 0.85 | BRD4 (0.39) | PARP1ACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL8817564 | 0.84 | ACHE (0.44) | DHODHPARP1ACHECHEK2 | |
| SCHEMBL8817619 | 0.84 | ACHE (0.40) | DRD3KCNH2DRD2PARP1ACHE | |
| SCHEMBL8817603 | 0.84 | ACHE (0.42) | PARP1ACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL8079505 | 0.83 | ACHE (0.46) | DHODHDRD3DRD2PARP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000506529-A | — | — | 2000-05-30 | — | — | JP | claimed |
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | claimed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |