Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | AOC1 | P19801 | 2/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12368482 | 0.81 | KAT2B (0.39) | KAT2BNR4A2GAATDP1PIK3CD | |
| SCHEMBL1621716 | 0.78 | KAT2B (0.37) | KAT2BNR4A2GAATDP1 | |
| SCHEMBL14243611 | 0.74 | SMN1; SMN2 (0.44) | GAA | |
| SCHEMBL3644982 | 0.70 | PIK3CD (0.34) | KAT2BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11831985 | 0.67 | TDP1 (0.40) | KAT2BNR4A2GAATDP1AOC1 | |
| SCHEMBL2037028 | 0.65 | POLB (0.47) | GAA | |
| SCHEMBL2074438 | 0.65 | GAA (0.42) | KAT2BNR4A2GAATDP1AOC1 | |
| SCHEMBL21182583 | 0.64 | KAT2B (0.38) | KAT2BNR4A2GAATDP1AOC1 | |
| SCHEMBL14549152 | 0.64 | SMN1; SMN2 (0.36) | TDP1 | |
| SCHEMBL22561865 | 0.63 | PDE10A (0.45) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009017822-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2009-02-05 | — | — | WO | disclosed |