Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619559 | 0.89 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL1618790 | 0.87 | PIK3CA (0.81) | PIK3CASMN1; SMN2TP53MAPTSCD | |
| SCHEMBL14748038 | 0.86 | PIK3CA (0.79) | PIK3CAMTOR | |
| SCHEMBL1619564 | 0.83 | PIK3CA (0.89) | PIK3CAMTOR | |
| SCHEMBL14747993 | 0.81 | PIK3CA (0.85) | PIK3CAMTOR | |
| SCHEMBL1620365 | 0.80 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL14747992 | 0.80 | PIK3CA (0.82) | PIK3CAMTOR | |
| SCHEMBL1621495 | 0.78 | PIK3CA (0.91) | PIK3CAMTOR | |
| SCHEMBL14747995 | 0.78 | PIK3CA (0.79) | PIK3CAMTOR | |
| SCHEMBL8089142 | 0.78 | PIK3CA (0.81) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017822-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2009-02-05 | — | — | WO | disclosed |