Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084184 | 0.89 | MAPT (0.63) | MAPTTP53POLBALOX15 | |
| SCHEMBL6952565 | 0.86 | ALOX15 (0.61) | MAPTTP53POLBALOX15 | |
| SCHEMBL6951542 | 0.84 | MAPT (0.49) | MAPTTP53POLBALOX15NOTCH1 | |
| SCHEMBL7241732 | 0.84 | MAPT (0.68) | MAPTTP53POLBALOX15 | |
| SCHEMBL9246649 | 0.83 | MAPT (0.67) | MAPTTP53POLBALOX15 | |
| SCHEMBL9246654 | 0.80 | MAPT (0.62) | MAPTTP53POLBALOX15 | |
| SCHEMBL6950377 | 0.76 | TP53 (0.48) | MAPTTP53POLBALOX15NOTCH1 | |
| SCHEMBL7245462 | 0.76 | MAPT (0.60) | MAPTTP53POLBALOX15 | |
| SCHEMBL11111931 | 0.76 | CACNA1F (0.65) | MAPTPOLB | |
| SCHEMBL10987755 | 0.75 | CACNA1D (0.55) | MAPTTP53NOTCH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066655-A | FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, IN PARTICULAR AS CEREBRAL THERAPEUTICS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-23 | — | — | US | disclosed |
| US-5731333-A | LEARNING AND MEMORY ENHANCEMENT, ANTIDEPRESSANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |