Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084427 | 0.76 | MEN1 (0.43) | NPY5R | |
| SCHEMBL8067810 | 0.74 | TRPV1 (0.31) | ALDH1A1 | |
| SCHEMBL8067806 | 0.71 | PAOX (0.41) | ALDH1A1 | |
| SCHEMBL8077346 | 0.71 | DPP7 (0.31) | TP53 | |
| SCHEMBL8082623 | 0.71 | TRPV1 (0.35) | ALDH1A1 | |
| SCHEMBL14739265 | 0.71 | GRIA1 (0.52) | GRIA1NPY5RPOLBCA1CA2 | |
| SCHEMBL14740061 | 0.71 | GRIA1 (0.52) | GRIA1NPY5RPOLBCA1CA2 | |
| SCHEMBL14739515 | 0.71 | GRIA1 (0.52) | GRIA1NPY5RPOLBCA1CA2 | |
| SCHEMBL14739086 | 0.71 | GRIA1 (0.52) | GRIA1NPY5RPOLBCA1CA2 | |
| SCHEMBL14739816 | 0.71 | GRIA1 (0.52) | GRIA1NPY5RPOLBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861231-B1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASEINHIBITORS | SEARLE & CO (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0861231-A1 | L-N?6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997010204-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-03-20 | — | — | WO | disclosed |