Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | RXRB | P28702 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257527 | 0.88 | RXRA (0.62) | RXRARXRBEGFRHCAR1TSHR | |
| SCHEMBL4651797 | 0.80 | TTR (0.60) | RXRARXRBTSHRALOX15SRD5A2 | |
| SCHEMBL9623395 | 0.79 | ABL1 (0.50) | TTRHSD17B10 | |
| SCHEMBL8432994 | 0.79 | CA1 (0.56) | EGFRCA12CA1CA2CA7 | |
| SCHEMBL10717595 | 0.78 | SRD5A2 (0.66) | RXRARXRBEGFRCA12CA1 | |
| SCHEMBL11717548 | 0.77 | ESR2 (0.48) | EGFRCA12CA1CA2CA9 | |
| SCHEMBL14886625 | 0.77 | RXRA (0.53) | RXRARXRBTSHRALOX15SRD5A2 | |
| SCHEMBL11219580 | 0.76 | TSHR (0.71) | RXRARXRBCA12CA1CA2 | |
| SCHEMBL670733 | 0.76 | BCL2L1 (0.57) | RXRARXRBHCAR1CA12TSHR | |
| SCHEMBL410759 | 0.74 | RXRA (0.66) | RXRARXRBEGFRTSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |