Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088661 | 0.87 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL8084447 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL7267833 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL7267642 | 0.85 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8085125 | 0.84 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL9299235 | 0.82 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL7266970 | 0.82 | ABCC9 (0.41) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL9300325 | 0.82 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8077161 | 0.82 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8088372 | 0.81 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |