Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092510 | 0.93 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8086535 | 0.87 | PTGS2 (0.61) | PTGS2PTGS1CHRNA7CA12CA1 | |
| SCHEMBL8086948 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1CHRNA7PTGDR2CA12 | |
| SCHEMBL8094129 | 0.82 | PTGS2 (0.63) | PTGS2PTGS1CHRNA7PTGDR2CA12 | |
| SCHEMBL8776868 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1CHRNA7PTGDR2CA12 | |
| SCHEMBL8094178 | 0.80 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL8093078 | 0.80 | PTGS2 (0.83) | PTGS2PTGS1CHRNA7CA12CA1 | |
| SCHEMBL8088327 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1CHRNA7CA12CA1 | |
| SCHEMBL8094137 | 0.79 | PTGS2 (0.64) | PTGS2PTGS1CHRNA7PTGDR2CA12 | |
| SCHEMBL8088323 | 0.79 | PTGS2 (0.63) | PTGS2PTGS1CHRNA7CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | claimed |
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |