Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470215 | 1.00 | LMNA (0.50) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL10573052 | 0.91 | ELANE (0.51) | ELANEPREPCTSGCMA1TAAR1 | |
| SCHEMBL22209430 | 0.91 | LMNA (0.53) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL18619671 | 0.91 | LMNA (0.53) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL3472006 | 0.89 | STAT6 (0.47) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL13928443 | 0.89 | STAT6 (0.47) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL7362814 | 0.87 | LMNA (0.53) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL3471466 | 0.87 | LMNA (0.53) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL20484733 | 0.87 | LMNA (0.53) | LMNAALDH1A1KMT2AHTTELANE | |
| SCHEMBL13924699 | 0.84 | ELANE (0.56) | LMNAALDH1A1KMT2AHTTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037363-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 2000-03-14 | — | — | US | disclosed |
| US-5907043-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1999-05-25 | — | — | US | disclosed |
| US-5739157-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |