Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.59 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 9/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053808 | 0.89 | MEN1 (0.52) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL3053593 | 0.89 | MEN1 (0.52) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL8089684 | 0.85 | MEN1 (0.56) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL4854445 | 0.83 | MEN1 (0.43) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL14193669 | 0.78 | SRC (0.50) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL3056032 | 0.76 | HTT (0.53) | MEN1KMT2ALMNANPSR1HTT | |
| SCHEMBL3053024 | 0.76 | HTT (0.53) | MEN1KMT2ALMNANPSR1HTT | |
| SCHEMBL16202886 | 0.75 | NPSR1 (0.80) | MEN1KMT2ALMNANPSR1HTT | |
| SCHEMBL2464129 | 0.74 | MEN1 (1.00) | MEN1KMT2ANR2F2LMNANPSR1 | |
| SCHEMBL27888661 | 0.73 | ALDH1A1 (0.49) | MEN1KMT2ALMNANPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0682027-B1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA GEIGY AG (CH) | 1997-10-15 | — | — | EP | disclosed |
| EP-0682027-A1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA-GEIGY AG (CH) | 1995-11-15 | — | — | EP | disclosed |