Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089650 | 0.85 | CCNT1 (0.47) | CCNT1CDK9EGFRPIM1CSF1R | |
| SCHEMBL7495538 | 0.84 | EGFR (0.56) | CCNT1CDK9ALDH1A1HPGDKDM4E | |
| SCHEMBL4899896 | 0.81 | EGFR (0.57) | ALDH1A1LMNAHPGDKDM4EPOLB | |
| SCHEMBL2459279 | 0.79 | EGFR (0.56) | ALDH1A1LMNAHPGDKDM4EEGFR | |
| SCHEMBL7495582 | 0.78 | CSF1R (0.59) | CSF1RCHUKCCNB2CDK1CCNB1 | |
| SCHEMBL333831 | 0.70 | CA12 (0.46) | ALDH1A1HPGDKDM4EPIM1 | |
| SCHEMBL7218007 | 0.69 | AURKA (0.65) | ALDH1A1LMNAHPGDKDM4EPOLB | |
| SCHEMBL14098811 | 0.69 | AURKA (0.65) | CCNT1CDK9ALDH1A1LMNAHPGD | |
| SCHEMBL7498032 | 0.68 | EGFR (0.59) | ALDH1A1HPGDKDM4EEGFRCHUK | |
| SCHEMBL10685704 | 0.68 | PDE2A (0.50) | ALDH1A1LMNAHPGDKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |