Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088077 | 0.85 | CCNT1 (0.47) | CCNT1CDK9EGFRCHUKINSR | |
| SCHEMBL7498032 | 0.84 | EGFR (0.59) | EGFRCHUKINSRMAPK8CAMKK2 | |
| SCHEMBL4903666 | 0.81 | EGFR (0.57) | EGFRCSF1R | |
| SCHEMBL7498302 | 0.78 | CSF1R (0.59) | EGFRCHUKCSF1R | |
| SCHEMBL2459279 | 0.75 | EGFR (0.56) | EGFR | |
| SCHEMBL333831 | 0.70 | CA12 (0.46) | PIM1 | |
| SCHEMBL7495538 | 0.68 | EGFR (0.56) | CCNT1CDK9EGFRCHUKINSR | |
| SCHEMBL16546225 | 0.68 | EGFR (0.57) | EGFRCSF1R | |
| SCHEMBL1897594 | 0.67 | EGFR (0.55) | EGFRCSF1R | |
| SCHEMBL5406265 | 0.67 | MAP3K14 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0682027-A1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA-GEIGY AG (CH) | 1995-11-15 | — | — | EP | disclosed |