Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088975 | 0.87 | HTR2A (0.60) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8088973 | 0.87 | HTR2A (0.60) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8095719 | 0.85 | HTR2A (0.58) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8095717 | 0.85 | HTR2A (0.58) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8088503 | 0.84 | HTR2A (0.56) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8102766 | 0.84 | HTR2A (0.56) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8098274 | 0.84 | HTR2C (0.56) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8098278 | 0.84 | HTR2C (0.56) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8088502 | 0.84 | HTR2A (0.56) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL8088925 | 0.83 | HTR2A (0.55) | HTR2CHTR2AHTR2BCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |