Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095717 | 1.00 | HTR2A (0.58) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8089150 | 0.90 | HTR2A (0.55) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8088925 | 0.90 | HTR2A (0.55) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8098278 | 0.89 | HTR2C (0.56) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8098274 | 0.89 | HTR2C (0.56) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8088973 | 0.87 | HTR2A (0.60) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8088975 | 0.87 | HTR2A (0.60) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8104663 | 0.87 | HTR2A (0.54) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8098116 | 0.87 | HTR2A (0.54) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL8102766 | 0.86 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |