SCHEMBL8089095

SCHEMBL8089095

NC(=O)C1CNCC(C(=O)O)C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 4/20 0.47
KMT2A Q03164 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPT P10636 1/20 0.47
ATM Q13315 1/20 0.47
CYP1A2 P05177 2/20 0.45
ALOX15 P16050 2/20 0.45
CYP2C19 P33261 2/20 0.45
SLC1A3 P43003 1/20 0.45
SLC1A2 P43004 1/20 0.45
SLC1A1 P43005 1/20 0.45
TSHR P16473 3/20 0.43
LMNA P02545 3/20 0.43
SLC6A1 P30531 2/20 0.43
SLC6A11 P48066 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
SLC6A13 Q9NSD5 1/20 0.43
NOS2 P35228 1/20 0.41
GABRP O00591 2/20 0.39
GABRD O14764 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1117719 0.88 CYP2D6 (0.54) CYP2D6KMT2ACYP1A2ALOX15CYP2C19
SCHEMBL8256069 0.88 CYP2D6 (0.54) CYP2D6KMT2ACYP1A2ALOX15CYP2C19
SCHEMBL17743413 0.85 CYP2D6 (0.52) CYP2D6KMT2ACYP1A2ALOX15CYP2C19
SCHEMBL1366389 0.80
SCHEMBL6409398 0.78 GABRR1 (0.46) CYP2D6KMT2AKDM4EMAPTATM
Hydrochloric Acid SCHEMBL3228194 0.78
Ammonia Solution, Strong SCHEMBL28141684 0.78
SCHEMBL4746646 0.78 GABRR1 (0.46) CYP2D6KMT2AKDM4EMAPTATM
Water SCHEMBL28310277 0.78
SCHEMBL6409392 0.78 GABRR1 (0.46) CYP2D6KMT2AKDM4EMAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127366-A ANTICARCINOGENIC OR ANTITUMOR AGENTS MERCK & CO., INC. (US) 2000-10-03 US disclosed
WO-2000016778-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 2000-03-30 WO disclosed
EP-0862435-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 1999-02-03 EP disclosed
US-5817678-A IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC MERCK & CO., INC. (US) 1998-10-06 US disclosed
EP-0862435-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 1998-09-09 EP disclosed
WO-1997018813-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1997-05-29 WO disclosed