Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089387 | 0.86 | AGTR2 (0.62) | TLR7AGTR2AGTR1 | |
| SCHEMBL8089312 | 0.86 | AGTR2 (0.55) | TLR7AGTR2AGTR1 | |
| SCHEMBL8089260 | 0.85 | TLR7 (0.49) | TLR7AGTR2AGTR1 | |
| SCHEMBL8094791 | 0.82 | AGTR2 (0.65) | TLR7AGTR2AGTR1 | |
| SCHEMBL8089253 | 0.79 | AGTR2 (0.75) | AGTR2AGTR1 | |
| SCHEMBL8092846 | 0.79 | PPARG (0.59) | AGTR2AGTR1 | |
| SCHEMBL8088471 | 0.79 | AGTR2 (0.53) | AGTR2AGTR1 | |
| SCHEMBL9700712 | 0.78 | TLR7 (0.58) | TLR7 | |
| SCHEMBL8088541 | 0.77 | AGTR2 (0.61) | AGTR2AGTR1 | |
| SCHEMBL8092218 | 0.77 | AGTR2 (0.60) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| EP-0505893-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1992-09-30 | — | — | EP | disclosed |