Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380161 | 0.86 | JAK2 (0.61) | SYKABL1MAP3K5BLKJAK2 | |
| SCHEMBL31339966 | 0.79 | CTSC (0.44) | SYKCDK1KDRAXLJAK2 | |
| SCHEMBL12519548 | 0.78 | SYK (0.67) | SYKABL1CDK5SRCEGFR | |
| SCHEMBL13166126 | 0.78 | SYK (0.67) | SYKABL1CDK5SRCEGFR | |
| SCHEMBL12801657 | 0.77 | SYK (0.51) | SYKCDK5EGFRKDRCDK4 | |
| SCHEMBL13606335 | 0.77 | AURKA (0.65) | SYKABL1CDK5EGFRBLK | |
| SCHEMBL13166092 | 0.77 | AURKA (0.65) | SYKABL1CDK5EGFRBLK | |
| SCHEMBL4561983 | 0.77 | JAK2 (0.58) | ABL1KDRAXLJAK2 | |
| SCHEMBL31327413 | 0.77 | CDK1 (0.57) | CDK5SRCEGFRCDK1CDK2 | |
| SCHEMBL31327412 | 0.77 | CDK1 (0.57) | CDK5SRCEGFRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |