Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | CD63 | P08962 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801284 | 0.88 | PAK1 (0.53) | SYKCD63MAPK8MAPK9PLK1 | |
| SCHEMBL12274826 | 0.84 | FLT3 (0.52) | SYKPLK1KDRFLT3KIT | |
| SCHEMBL12801596 | 0.79 | MAPT (0.58) | SYKCD63MEN1KMT2AFLT3 | |
| SCHEMBL17573404 | 0.78 | KDR (0.49) | SYKPLK1BRD4KDRCDK5 | |
| SCHEMBL8089927 | 0.77 | SYK (0.54) | SYKKDRCDK5EGFRJAK2 | |
| SCHEMBL12801614 | 0.77 | SYK (0.55) | SYKCD63PLK1CDK5MEN1 | |
| SCHEMBL14254047 | 0.74 | ITK (0.53) | SYKMAPK8MAPK9PLK1KDR | |
| SCHEMBL12999380 | 0.74 | JAK2 (0.52) | MAPK8MAPK9PLK1BRD4KDR | |
| SCHEMBL13169823 | 0.73 | BRD4 (0.49) | MAPK8MAPK9PLK1BRD4KDR | |
| SCHEMBL4560068 | 0.73 | JAK1 (0.58) | BRD4KDRJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |