Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 4/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1185901 | 0.98 | GSK3B (0.47) | GSK3BKDM4EKMT2ATOP1ALDH1A1 | |
| SCHEMBL1185781 | 0.95 | KDM4E (0.45) | GSK3BKDM4EKMT2ATOP1ALDH1A1 | |
| SCHEMBL1185913 | 0.85 | STAT3 (0.47) | GSK3BKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL2191820 | 0.84 | GSK3B (0.46) | GSK3BKDM4EKMT2ATOP1ALDH1A1 | |
| SCHEMBL1185837 | 0.83 | STAT3 (0.47) | GSK3BKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL9872072 | 0.82 | KDM4E (0.63) | GSK3BKDM4EKMT2ATOP1ALDH1A1 | |
| SCHEMBL1186154 | 0.80 | STAT3 (0.48) | KDM4EKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL15090760 | 0.80 | KDM4E (0.46) | KDM4EKMT2ATOP1ALDH1A1POLB | |
| SCHEMBL12873913 | 0.79 | GSK3B (0.63) | GSK3BPOLBTOP2ATOP2B | |
| SCHEMBL1185725 | 0.77 | GSK3B (0.63) | GSK3BPOLBTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009035684-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |