Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088661 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8077042 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| Bimakalim SCHEMBL231904 | 0.84 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9299692 | 0.83 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL7269375 | 0.83 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9300068 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8084938 | 0.82 | MAOB (0.38) | MAOBGLAABCC9GPR119TRPV4 | |
| SCHEMBL9299687 | 0.81 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9300071 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9299283 | 0.80 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |