Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300071 | 0.85 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299692 | 0.84 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299222 | 0.83 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9300068 | 0.83 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299769 | 0.83 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299801 | 0.83 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299131 | 0.82 | ALOX5 (0.39) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299133 | 0.82 | ALOX5 (0.39) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299657 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8090538 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296492-A | Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0518342-A1 | Chroman derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-12-16 | — | — | EP | disclosed |