Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 19/20 | 0.89 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL809123 | 0.94 | NR3C1 (1.00) | NR3C1PGRKDM5AKDM4CKDM5B | |
| SCHEMBL808953 | 0.88 | NR3C1 (0.89) | NR3C1PGR | |
| SCHEMBL809105 | 0.87 | NR3C1 (0.89) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL809173 | 0.84 | NR3C1 (0.89) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL2143635 | 0.82 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL821013 | 0.81 | NR3C1 (1.00) | NR3C1 | |
| SCHEMBL809247 | 0.78 | NR3C1 (1.00) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL809018 | 0.76 | NR3C1 (0.89) | NR3C1 | |
| SCHEMBL809160 | 0.73 | NR3C1 (0.89) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL808959 | 0.72 | NR3C1 (0.61) | NR3C1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-B9 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |
| EP-1776119-B1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-01-18 | — | — | EP | claimed |
| US-7902224-B2 | Tetrahydro-naphthalene derivatives as glucocorticoid receptor modulators | GLAXO GROUP LIMITED (GB) | 2011-03-08 | — | — | US | claimed |