SCHEMBL8090833

SCHEMBL8090833

Cc1ccc2c(C)ccc(O)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 1.00
OPRK1 P41145 1/20 1.00
CTSB P07858 1/20 0.57
CTSH P09668 1/20 0.57
HTT P42858 2/20 0.53
SLC6A2 P23975 1/20 0.53
METAP2 P50579 1/20 0.52
MAPT P10636 3/20 0.46
RAB9A P51151 3/20 0.44
CCR1 P32246 2/20 0.44
CCR5 P51681 2/20 0.44
KDM4E B2RXH2 8/20 0.44
ALDH1A1 P00352 5/20 0.44
HPGD P15428 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CCR8 P51685 1/20 0.40
USP2 O75604 1/20 0.40
NPC1 O15118 2/20 0.38
LMNA P02545 2/20 0.38
TP53 P04637 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3275602 0.87 KMT2A (0.77) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL7171554 0.85 KMT2A (0.74) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL28898898 0.83 KMT2A (0.71) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL6177657 0.82 KMT2A (0.69) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL31186674 0.82 KMT2A (0.69) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL4703454 0.80 KMT2A (0.67) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL1461144 0.80 KMT2A (0.67) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL7692195 0.80 KMT2A (0.67) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL4286016 0.79 KMT2A (0.65) KMT2AOPRK1CTSBCTSHHTT
SCHEMBL4304569 0.79 KMT2A (0.65) KMT2AOPRK1CTSBCTSHHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240299400-A1 Transcription Factor GLI1 Inhibitors and Uses Thereof UNIVERSITY OF CONNECTICUT (US) 2024-09-12 US disclosed
US-9601704-B2 Organic light-emitting device and display apparatus CANON KABUSHIKI KAISHA (JP) 2017-03-21 US disclosed
US-9466804-B2 Organic light-emitting element CANON KABUSHIKI KAISHA (JP) 2016-10-11 US disclosed
US-20150364703-A1 ORGANIC LIGHT-EMITTING DEVICE AND DISPLAY APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-12-17 US disclosed
US-20150357587-A1 ORGANIC LIGHT-EMITTING ELEMENT SAMSUNG ELECTRONICS CO., LTD. (KR) 2015-12-10 US disclosed
US-20150333279-A1 ORGANIC LIGHT-EMITTING ELEMENT AND DISPLAY APPARATUS SAMSUNG ELECTRONICS CO., LTD. (KR) 2015-11-19 US disclosed
US-6140341-A FOR TREATING PAIN HOECHST AKTIENGESELLSCHAFT (DE) 2000-10-31 US disclosed
EP-0795547-B1 (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists HOECHST AG (DE) 2000-05-10 EP disclosed
EP-0795547-A1 (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240299400-A1 Transcription Factor GLI1 Inhibitors and Uses Thereof GLI1, GLI2, SHH KMT2A 680/4885OPRK1 4580/4885CTSB 2337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.