Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093656 | 0.97 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8090321 | 0.94 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8091731 | 0.92 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8101095 | 0.92 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8097958 | 0.90 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8093437 | 0.90 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8090381 | 0.89 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8105037 | 0.89 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8096243 | 0.88 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8093344 | 0.87 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |